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KMID : 1033620160430030181
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Clinical and Experimental Reproductive Medicine
2016 Volume.43 No. 3 p.181 ~ p.184
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Live birth in a woman with recurrent implantation failure and adenomyosis following transfer of refrozen-warmed embryos
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Safari Somayyeh
Faramarzi Azita
Azam Agha Rahimi
Khalili Mohammad Ali
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Abstract
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The aim was to report a healthy live birth using re-vitrified-warmed cleavage-stage embryos derived from supernumerary warmed embryos after frozen embryo transfer (ET) in a patient with recurrent implantation failure (RIF). The case was a 39-year-old female with a history of polycystic ovarian syndrome and adenomyosis, along with RIF. After ovarian hyperstimulation, 33 cumulus-oocyte complexes were retrieved and fertilized with conventional in vitro fertilization and intracytoplasmic sperm injection. Because of the risk of ovarian hyperstimulation syndrome, 16 grade B and C embryos were vitrified. After 3 and 6 months, 3 and 4 B?C warmed embryos were transferred to the uterus, respectively. However, implantation did not take place. Ten months later, four embryos were warmed, two grade B 8-cell embryos were transferred, and two embryos were re-vitrified. One year later, the two re-vitrified cleavage-stage embryos were warmed, which resulted in a successful live birth. This finding showed that following first warming, it is feasible to refreeze supernumerary warmed embryos for subsequent ET in patients with a history of RIF.
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KEYWORD
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Adenomyosis, Embryo, Live birth, Vitrification
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